AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein

نویسندگان

  • Hee Ho Lee
  • Myunghan Bae
  • Sung Hyun Jo
  • Jang-Kyoo Shin
  • Dong-Hyeok Son
  • Chul-Ho Won
  • Hyun-Min Jeong
  • Jung-Hee Lee
  • Shin-Won Kang
چکیده

In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed biosensor was varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor with null-balancing circuit applied shows that CRP can be detected in a wide range of concentrations, varying from 10 ng/mL to 1000 ng/mL. X-ray photoelectron spectroscopy was carried out to verify the immobilization of self-assembled monolayer with Au on the gated region.

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عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2015